This documentary series follows four transgender college students as they deal with personal discoveries, family issues and financial and academic challenges during the school year. Two female to male (FTM) and two male to female (MTF) young people open up their lives.

TJ is Armenian and came from Cyprus to Michigan State University, where he is a graduate student. FTM, TJ has not begun a physical transformation. He is obligated to return to Cyprus by the terms of his Fulbright Scholarship, but his mother is clear that he cannot be "gay" in Cyprus. TJ is the only one of the four students in a relationship, with a girlfriend who is fine with his male identity.

Lucas is a FTM senior at Smith College, dealing with the complexities of identifying as male at an all women's school. His best friend Kasey undergoes top surgery, while Lucas begins taking testosterone after careful consideration. Visits with family in Oklahoma go well.

Raci is a Filipina freshman at Cal State LA. Hearing impaired, she is pre-op MTF and so feminine that she usually easily passes as a woman. Raci is on an academic scholarship and struggles financially, buying hormones on the street and living in a boarding house where she shares a bed with her aunt.

Gabby is a sophomore MTF at the University of Colorado at Boulder. Somewhat self centered and a social misfit, identifying as a lesbian or perhaps bisexual, she undergoes sex reassignment surgery. Her parents are easily able to afford the required $15,000, although they struggle with understanding Gabby and her obsession with the surgery.